Stability Test Chamber

Companies buy walk-in stability test chamber for different reasons. The most obvious need is size. Large or odd-shaped products are not necessarily suitable for the scope of the floor model test chamber, especially when you consider the airflow ratio (the volume of the product and the volume of the work space are one to three). Other companies choose walk-in test chambers to accommodate a large number of products (thousands of mobile phones, for example), or to allow engineers to observe products up close during testing. The former case can improve the test efficiency, the latter case is only possible in a huge internal working space. The walk-in stability test chamber can be customized according to the volume and shape, performance, air quality (if people stay in the chamber), etc. You can even add an anteroom to separate the test chamber space from the laboratory. So, although you can find similar performance in floor-standing models (or desktops for that matter), you can only achieve this level of customization through a walk-in test chamber. Advantage The size is almost unlimited, so a lot of shelf space/samples can be accommodated A qualification covers a lot of shelf space Due to the larger size, the conditions of walk-in test chamber tend to be more stable Shortcoming A defective chamber can cause problems with a large number of samples Installation usually requires construction, electronics and refrigeration skills The compressor will increase the floor space or the distance, so it will increase the cost Identification requires additional probes Spare parts may be unique to the special construction They usually require three-phase power and additional water supply For safety reasons, the time the operator spends indoors may be limited Island space is necessary footprint waste There are many factors to consider when researching a walk-in test test chamber. With such a large capital purchase, you cannot ignore any details. Consult your entire team. Work hard to understand your testing requirements. Most importantly, contact an experienced test chamber manufacturer who can build a customized solution within your budget. Learn more about XCH Biomedical custom walk-in constant stability chamebr series.

Sunlight is a powerful force. The sun emits radiation in most of the electromagnetic spectrum, including a large amount of ultraviolet radiation. Although part of the solar radiation is absorbed by the earth’s atmosphere, there is still a considerable amount of radiation reaching the earth’s surface (as shown in the picture on the right). Ultraviolet rays can break the molecular bonds in the objects they strike. Most people are familiar with this effect on old paper products and other items. When they are exposed to sunlight, the chemical bonds are broken down, causing the color to fade. This discoloration effect is called photo degradation. However, the color of the object is not the only thing affected. The chemical properties of objects are affected, so these effects are extremely important to the pharmaceutical, cosmeceutical, and nutraceutical industries. There is a need to avoid chemical breakdown in drugs or vitamins, so it is important to ensure that drugs and nutrients remain stable during the expected shelf life of exposure to light. This is done by testing the light stability of the product. Light stability affects product shelf life, handling and packaging. This test is an important part of the drug development process. Light stability studies are usually conducted in a continuous manner, first testing drugs/supplements. Then, the product is tested first in its direct packaging, followed by the final marketing packaging that will be placed on the retailer's shelf. These tests can be repeated repeatedly until they prove that the drug can be sufficiently protected from light. Pharmaceutical manufacturers must establish the stability of their drugs to light. But what makes drug molecules or preparations unstable to light, and how to give them proper protection? Why do drug molecules degrade under light? First, drug molecules can directly absorb light. For this reason, the spectrum of the light source must overlap with the absorption spectrum of the molecule to some extent. Therefore, molecules that can absorb light of 320 nm or higher are at risk of photostability. The second way light causes photodegradation is through a process called photosensitization. This is where another component of the formulation absorbs light energy and then transfers it to the drug molecule, leading to degradation. To illustrate this effect, Figure 4 shows the structure and UV absorption spectrum of Losartan. We do not want losartan to have a photodegradation risk, and it has been proven to be photostable in most formulations. However, in liquid oral preparations containing cherry flavoring, losartan is sensitive to light [2]. Of course, cherry flavoring is colored and can absorb light. In addition, in the presence of oxygen, degradation occurs faster. The photodegradation reaction usually proceeds through the oxidation pathway. All companies that develop or manufacture drugs require a robust light stability testing process to ensure product quality and regulatory compliance. Inadequate testing can lead to costly delays and lost revenue. The 1996 guideline CPMP/ICH/279/95 Q1B describes the process of light stability testing of new active substances and pharmaceutical products. The output of cool white fluorescent lamps is similar to the output specified in ISO 10977 (1993). The spectral distribution of UVA fluorescent lamps is 320 nm to 400 nm, and the maximum energy emission is between 350 nm and 370 nm. Most waves must be in the range of 320 nm to 360 nm and 360 nm to 400 nm. The sample should be exposed to at least 1.2 million lux-hours under visible light (VIS) and at least 200 watt-hours per square meter under UVA. For more information, please refer to thchamber Photo Stability Test Chamber product page.

What is a stability test chamber? Most stability test chambers are similar to a large scientific refrigerator. Their function is not to keep the contents cool, but to replicate changes in temperature, humidity, and light for a long time. This is crucial when a pharmaceutical company wants to bring a new product to the market. Changes in temperature, humidity, and light are closely related to the recommended shelf life of medicines. If you check your medicine cabinet, you will most likely find the "expiration date" on prescriptions and headache medicines. We will focus on medicines here, but they are equally applicable to many products whose performance and reliability must remain unchanged under many climatic conditions around the world. Before you buy a test room, you must first determine the standard you want to test. These will determine the specific test room you need. When you need to pick up the phone, you will also know what you are looking for. I hope the manufacturer has stock and can give it to you in time. However, the inventory exceeds the availability. Check the manufacturer's website. Are the sizes and types of the listed models different-temperature and humidity, temperature control, etc.? Does it come with a standard and high-performance test chamber? What are its customization options and upgrades? These may not apply to you, but more products show that the manufacturer has a solid team of engineers behind its products, and has done a good enough job in sales, it is worth choosing a variety of test boxes. The best test room manufacturers maintain communication for a long time after the initial transaction and provide support when needed. Many provide free replacement parts and services during the warranty period after your purchase. Also, look for the types of troubleshooting available so that you don't always have to rely on external services to keep running and identify the problem before you bring in the service team. However, the real difference lies in the long-term maintenance plan. You must perform preventive quarterly and annual maintenance to keep your test room running. Look for factory service employees instead of HVAC technicians. If you can cooperate with the manufacturer's service department for maintenance, that would be an advantage. They understand the intricate details of environmental test chambers, which are much more complicated than typical HVAC maintenance and repairs. In addition, working with factory services can help you build a working relationship that you can turn to when problems or problems arise. Want to know what the best environmental test chamber manufacturer must provide? Contact XCH Biomedical to learn how we use the latest laboratory technology and solutions to provide services to companies from all walks of life. XCH Biomedical R & D Technical Team The company is backed by scientific research institutes, exerts its own talent advantages, and continuously applies the latest achievements to products. The R&D team led by researchers and Ph.D. thermal engineering has always been serious and rigorous; we understand that you are under pressure to quickly introduce new products to the market. Products must be tested under various conditions to ensure their quality and reliability. Products and Services 1. Biological field: Use biotechnology to conduct environmental tests on new products. Provide sophisticated experiment and test equipment to ensure product reliability. 2. Medical field: From syringes, vaccines to pacemakers, the medical industry needs to understand the limitations of temperature, use and storage, and strictly control the manufacturing and research and development of products. We provide various environmental test chambers and test chambers for stability testing and storage of products or tools in the medical field to ensure effectiveness and reliability.

The R&D team led by researchers and Ph.D. thermal engineering has always been serious and rigorous. The company has its own standard factory buildings, standard testing laboratories and sheet metal processing equipment, and has subsidiaries in Jiangsu, Shanghai, Guangzhou, and Chengdu, as well as offices in China. Other provinces. In the life and health business, we can only work hard, and we can't slacken our efforts! Drug stability is XCH Biomedical best-selling product. Many customers change their orders to us. Why do they choose XCH Drug Stability Test Chamber? XCH-CGS drug stability test chamber is designed with imported technology, imported high-quality components, S platform, and reliable performance. Applicable to GMP certified users. The advantages are as follows: The newly designed airway system makes the temperature and humidity of different parts of the room even; using polyurethane foaming technology, it has good heat preservation and moisturizing properties. The original imported VAISALA humidity sensor has high accuracy, small drift, long life and maintenance-free. The original imported fully enclosed industrial compressor has high efficiency and low noise, ensuring long-term continuous operation of the equipment. Original imported programmable color touch screen controller, sensitive, small system error, multi-segment program setting and multi-point precise calibration function, three-level password. There is a 25mm diameter test hole on the left side of the box. The inner toughened glass door and outer door are specially designed for observing samples, and will not cause changes in temperature and humidity in the box in a short time. Door locks and movable casters can be locked. The inner tank is made of mirror stainless steel 304, no pollution source, easy to clean. GMP quality assurance dual data acquisition system: standard needle printer can print the device model and serial number to meet the requirements of data integrity and consistency. SD card storage, can store electronic text data for more than 5 years; free software, can import SD card data into the computer system. Safety device: C compressor unit overheating and overpressure and overload protection, water shortage protection, dry burning protection system, independent overheating protection alarm system; Alarm system: sound and light alarm for temperature and humidity deviation, remote temperature and humidity deviation and short message alarm for power failure. Power supply: AC 220V±10% 50HZ; Ambient temperature: +5 ～35℃; Temperature fluctuation: ≤±0.5℃, temperature deviation: ≤±1.0℃; humidity deviation: ≤±3%RH

Human beings are very dependent on drugs from birth. Poliomyelitis drops, vaccines, wound treatments, eye drops, medications for the elderly. There are different drugs for different life stages. These drugs are produced using chemical analysis, biotechnology, microbial cultures, etc. These medicines are just drops of life. If it is produced incorrectly, it can be devastating for the person who eats it, leading to his death. Different types of stability studies have been carried out for these aspects. Established a medical compliance agency. ICH, USFDA and other institutions were established. These pharmaceutical compliance agencies have established standards for manufacturers to follow. Unless these compliance agencies do not provide them with a license to do so, it can ensure that pharmaceutical manufacturers cannot market or sell their products. Before issuing a license, the pharmaceutical agency will check the QA analysis of the drugs produced. It is necessary to check the chemical composition, check the uniformity of the drug, and check the behavior of the drug under different climatic conditions. Pharmaceutical manufacturers need to check the behavior of their products through different stages of quality analysis. One of the stages is "stability". The stability of the product in different environments. Different environmental conditions, such as humidity, temperature, ultraviolet radiation, etc., are artificially generated in a stable room. Heat, humidity and light are all causes of product degradation. Regulatory committees, such as the Federal Drug and Food Administration (FDA), ensure that appropriate precautions are taken to maintain consumer safety. Establishing product integrity in different climatic zones is critical, because small changes in temperature and humidity will affect the drug. Carry out stability storage and test studies to simulate climate effects. These studies are based on where the product is sold. Understanding all the ways in which finished products or active pharmaceutical ingredients (APIs) are affected by degradation is critical to the storage of these products. Through these studies, XCH Biomedical can determine the shelf life of the drug, determine the best storage method for the drug, and ultimately help ensure the safety of consumers. What is a stability test chamber? Most stability test chambers are similar to a large scientific refrigerator. Their function is not to keep things cool, but to replicate changes in temperature, humidity, and light for a long time. For example, this is critical when a pharmaceutical company wants to bring a new product to the market. 1. Humidity test The accuracy and repeatability, reliability and durability of the parameters in continuous operation are the primary tasks of the humidity test chamber. The sturdy stainless steel interior should be corrosion resistant and designed to be easy to clean. The programming must be intuitive, and the documentation must meet the requirements of FDA 21 CFR Part 11. Calibration certificates, data loggers and verification documents should of course also be included. 2. Light In the case of light stability test according to ICH Q1B, light supplement temperature and humidity are used as additional parameters. Specify the light source and lighting level for each time unit. Visible light (VIS is similar to ISO 10977 (1993)) must reach an exposure time of at least 1.2 million lux per hour, and near ultraviolet light must be at least 200 hours/m² (320 nm to 400 nm). As with temperature and humidity, uniform light distribution on each shelf is critical. Here, the basic specifications are the intensity distance, and the type of sensor and reflector used 3. Accelerated research or forced degradation is used to predict the shelf life of products. Scientists accelerate the process and speed of decomposition/degradation by increasing the temperature and/or humidity of environmental conditions in a short period of time. These accelerations indicate that if it is introduced to extreme conditions in a short period of time, it will have an impact on the drug. Overall, this gives a general overview of the different characteristics of degradation, including physical, chemical, and microbiological.