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  • Temperature Alert Systems for Lab Refrigerators Matter
    Mar 22, 2022
    Why Lab Refrigerator Temperature Alarms Are Crucial What could go wrong? Perhaps the first thing that comes to mind is a power failure. If your facility does not have emergency generators that come online immediately, you need a backup plan to quickly move production to a backup refrigeration system. Less likely, but not unknown, is a mechanical failure in the refrigeration system or a temperature excursion due to poor maintenance, such as icing on the evaporator coil. Another example is accidentally leaving the unit's door ajar. As a final example in this post, a temperature monitor that activates an alarm can fail. For whatever reason, personnel must be alerted if the temperature is above or below the set value. Quick response to temperature excursions helps protect contents from spoilage or loss of potency. Temperature alarm system To understand the alarm system, we first set up the stage. Temperature alarms are programmed by personnel based on the proper storage temperature of materials in freezers and refrigerators. Use a mechanical or digital thermostat to set the temperature. Temperature monitors consist of probes placed in refrigerators and freezers and connected to onboard or external display and control devices. Many of these come with battery backup to maintain functionality in the event of a power failure. For more information on temperature controls and monitors, see our post on the topic of vaccine storage. On-board alarm Examples of on-board systems include Nor-Lake Scientific laboratory freezers and refrigerators available from Tovatech. These feature digital LED microprocessor temperature controllers with high/low visual and audible temperature alarms and remote alarm contacts to alert personnel elsewhere in the facility. A temperature sensor is placed in the bottle filled with glycerin to better reflect the temperature of the contents than the ambient temperature in the unit. Such an arrangement also reduces the chance of triggering an alarm when the unit door is opened. Some models of Scientific Refrigeration systems provide power failure alarms and door ajar alarms. Auxiliary or optional alarm system General purpose laboratory refrigerators and freezers can be equipped with an optional digital thermometer alarm consisting of an internal probe housed in a glycerin-filled bottle that is wired to external control and alarm devices. Probably the best solution for notifying refrigeration failures is the iLab 600 temperature monitoring system from Tovatech. The device operates independently of the device by collecting data from an internal probe connected through an access port to an external pod, which in turn is connected to the facility's LAN. The iLab 600 has two functions: A sophisticated programmable high/low temperature alarm that sounds locally and sends email, text, phone or pager alerts to the personnel list during off hours. It also captures, remotely stores and instantly retrieves compliance data reports on laboratory freezer and laboratory refrigerator performance. An optional USB temperature data logger with built-in alarm can be used to automatically record internal temperature at user-programmable intervals using a NIST traceable probe. To read the results, simply plug the USB flash drive into the computer and transfer the data to the PC for viewing and archiving. In addition to the onboard and optional digital thermometer alarms, an iLab 600 or USB data logger is recommended for two reasons. First, you shouldn't rely on a single temperature sensor to drive a temperature warning system. There should be at least two completely separate monitoring systems with alarms linked to separate temperature sensors. Second, they provide a way to acquire, store and retrieve stored temperature data based on good laboratory and good manufacturing processes. Other Pharmaceutical Refrigerator Tips Despite sophisticated temperature monitoring and alarm systems, laboratory personnel have a responsibility to protect the contents of refrigerators and freezers from spoilage due to improper storage temperatures.   Be prepared for prolonged power outages. Large facilities should have a backup emergency power system to keep refrigerators and freezers functioning properly. Smaller labs can use portable generators. If they shouldn't have procedures in place to quickly move valuable specimens, vaccines and medicines to off-site locations. Keep in mind that full freezers and refrigerators will keep the temperature longer. Fill the empty space with an ice pack or water bottle. Minimize unit visits. Temperature fluctuations occur every time the door is opened. Publish operating procedures for monitoring and recording temperatures twice a day and instruct personnel to respond to power outages. Contact Thchamber  Laboratory Freezer Manufacturer for details on protecting the contents of laboratory freezers and refrigerators from temperature excursions.
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  • How to use and maintain your laboratory incubator
    Mar 15, 2022
    A Precision Lab Incubator Equipment from china Laboratory Incubator Manufacturer is an important piece of equipment in any laboratory, but reliable results require the proper use and maintenance of your equipment. What's more, some models can get quite expensive, and you may not want to replace your machine as often. 1. Position your device correctly Proper placement of your equipment ensures that it operates efficiently and minimizes exposure to potential contaminants. When choosing the best location for your laboratory incubator, you need to consider the following factors: Doors and vents can blow in pollutants and increase the chance of fungal growth. What's more, they create airflow that affects the temperature stability of the device. Direct sunlight can cause temperature fluctuations and problems with the anti-condensation feature. You need enough space (at least three inches) around the device so that heat can escape and power cords and outlets are easily accessible. Place floor-standing incubators on shelves to reduce the risk of influx of contaminants when the door is open. Avoid damp, damp areas where fungus can grow. Place the device away from sources of vibration, such as shakers, blenders, or refrigerators, as vibration can affect cell growth. Make sure the area around the device is as clean as possible. The ideal conditions for a laboratory incubator are a temperature-controlled environment and clean room conditions. Since this is usually neither practical nor feasible, considering the above factors is sufficient for most applications. 2. Monitor the temperature The thchamber heating incubator is typically maintained at 37°C for optimal growth of cell cultures. Temperature deviations can inhibit growth or even destroy cultures. A temperature sensor is included in the unit, but how do you know you can always rely on your sensor? One way to ensure the correct temperature is to use a second thermometer. If your incubator has a glass door, you can install a calibrated thermometer inside the glass and read it without opening the door. You can check this against the sensor temperature and if they are different you know the sensor needs to be recalibrated. Avoiding opening and closing doors unnecessarily helps keep the temperature stable (and prevents contaminants from entering the chamber). If you are concerned about the incubator door being opened unintentionally, you can choose a unit with a door lock. 3. Monitor humidity and carbon dioxide Optimal growth conditions for cell cultures also include specific humidity levels and, in some cases, CO2 levels. Tissues and cells are sensitive to changes in these parameters and therefore require close monitoring. If the humidity is too low, your cell culture medium may evaporate, or your growth medium may become too concentrated. The ideal humidity is usually around 95%, to keep it at this level you need to ensure that the water pan (under the incubator) is never at risk of drying out. For CO2 incubators, you need to monitor CO2 levels. This is usually kept at 5% to maintain a constant pH for optimal growth. The CO2 sensor helps by indicating when and how much CO2 needs to be added to the chamber. You can check CO2 levels every few months with an external gas analyzer. 4. Regular temperature calibration We discussed monitoring temperature above, but thermometers should also be regularly verified and calibrated. The exact timeline will depend on your application, but each month is a good guide. The unit should also be recalibrated if verification determines that the unit is required and after an abnormal event such as a power outage or spill cleanup. For reproducible results, calibration should be performed at normal operating temperatures. For incubators used in critical or sensitive experiments, you should also consider arranging for annual calibration by an external facility.
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  • How to store vaccines safely
    Mar 09, 2022
    With the advent of the COVID-19 epidemic in 2020, human beings have to coexist with the new coronavirus. It's time for healthcare facilities to pay close attention to their refrigeration equipment for vaccine storage and temperature monitoring. This article summarizes their advice on how to store Covid-19 vaccines safely. How to Choose a Vaccine Refrigerator for Safe Vaccine Storage Vaccine storage temperature is determined by the manufacturer. Typically, most refrigerated vaccines must be stored between 2⁰ and 8⁰C. Frozen vaccines should be stored between -50⁰ and -15⁰C. The first guideline for VFC-compliant vaccine storage is that the refrigeration system does not allow temperatures above or below recommended storage temperatures. Set your refrigerator or freezer thermostat to the factory setting or midpoint temperature, which will reduce the chance of temperature excursions. That's because over the years, when refrigerators used to store vaccines fail to keep vaccines at recommended temperatures, huge financial losses can occur. These temperature excursions can cause vaccines to lose efficacy. In addition to the financial loss, there is the inconvenience of calling patients back for re-vaccination without compromise. For example, Carmen Heredia Rodriguez of Kaiser Health News published an article in February 2019 titled "Vaccines are sometimes stored improperly, reducing their effectiveness." This article covers temperature control events in California and Indiana. The most important thing to store vaccines is to use separate vaccine refrigerators and freezers. That's because they hold the desired temperature better than a combination refrigerator/freezer. The exception is a combination vaccine refrigerator and freezer if each compartment has its own compressor, thermostat and exterior door. The organization notes that stand-alone units can range in size from pharmaceutical-grade compact, above- or below-counter units to full-size units. Home refrigerators are not recommended under any circumstances. The CDC even said that such devices are prohibited from being used to store VFCs or other vaccines purchased with public funds. Vaccine Storage Tips Regardless of the capacity of your vaccine refrigerator or freezer, there are a few "must dos" to keep in mind: A full unit will hold the temperature better, but don't overfill. Leave room for air circulation. Replace the removed refrigerator stock with a pre-chilled water bottle. Replace the removed freezer with a chilled water bottle. Allow space for circulation between containers and keep contents 2-3 inches from the walls and back of the unit. Post notes that food and beverages have no place in the vaccine storage unit. Keep contents in original packaging with expiry date up front. If your unit has door racks, fill them with frozen or frozen water bottles, not vaccines. Vaccine temperature is better. Designate a person to perform this task. It also provides an opportunity to monitor vaccine stocks. Contact the scientists at China Medical Refrigerator Manufacturer thchamber to learn more about choosing the right vaccine refrigerator equipment for your practice.
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  • The development history of environmental test chamber
    Mar 01, 2022
    Believe it or not, most of the technologies we take for granted today would not be possible without an environmental test chamber. At the heart of research and development, environmental test chambers are used to determine product performance, reliability, strength and failure points in many industries. Today, environmental test chambers vary in performance, size and capability. They are critical to a wide range of industries, from small handheld devices to electric vehicles. The first formal environmental laboratory was not invented until 1951 by Charles Conrad. He does this by altering his home refrigerator to achieve extremely cold temperatures as low as -125°F. New environmental testing techniques take off from there. With the expansion and formalization of environmental testing, special types of temperature, humidity, corrosion, vibration and other test chambers began to appear. Below are some common types of environmental test chambers today, ranging in size from small benchtop models to walk-in or drive-through rooms. Temperature and humidity chamber Using a precisely calibrated heating and cooling system, the  temperature and humidity chamber must maintain precise control of the test environment. The fast rate of change simulates the weather conditions a product may encounter during its life cycle, while maximizing test time for efficiency. Today, you can expect temperature accuracy to within ±0.5°C and relative humidity (RH) accuracy to within ±2%. The constant temperature and humidity chamber can be used for drug stability testing, battery testing, temperature cycling, solar testing, stress screening, HALT and HASS testing, etc. Industry leading temperature and humidity chambers capable of -70°C to +180°C (-94°F to 356°F) range and produce standard RH ranges between 20% and 95%. Using a high humidity sensor, some chambers can reach 98% RH or as low as 5% RH desiccant air dryers. Laboratory oven Commonly used for aging, baking, curing, drying and sterilization, laboratory ovens and liquid cooling ovens are also used for R&D, product design and testing. Test chambers have grown stronger over the past few decades and have continued to evolve over time. For example, Thchamber can remotely monitor ongoing tests. Manufacturers are also keeping pace with the growing importance of battery testing. They designed fixtures that fit in the test chamber to accommodate test batteries for everything from battery fonts to medical devices, drones, electric vehicles, and more. Most of our technological advancements are as good as our environmental testing techniques, which help explain the explosion of innovation and new technologies we've seen over the past 80 years. It is exciting to imagine what will happen to environmental testing technology in another half century.
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  • Importance of Vaccine Storage Refrigerator
    Feb 22, 2022
    Since the outbreak of the new crown epidemic, vaccines have always been the topic of most concern to everyone. Therefore, the world is very concerned about the unique storage conditions required for vaccines. Some of these new vaccines require ultra-low temperature storage chamber at or near -80°C, while others require storage at higher temperatures such as -20°C. Whether new vaccines or traditional vaccines, the storage conditions listed by manufacturers usually specify that vaccines need to be stored at +2°C to +8°C prior to administration, and that they must be prevented from freezing to protect their viability. One would think that freeze protection would be a no-brainer for a refrigerator. However, with temperature storage requirements so close to freezing, any issues with refrigerator temperature control or anything that might impede airflow, such as excessive inventory overloads, could put the product at risk. In fact, a 2012 report by the DHHS Inspector General stated that the vast majority of clinical providers they studied allowed vaccine exposure to inappropriate temperatures, which compromised potency and efficacy and put vaccine recipients at unnecessary risk . To help combat inappropriate storage conditions, CDC, in partnership with the National Science Foundation (NSF) International and the American National Standards Institute (ANSI), formed a committee to develop guidelines for vaccine refrigerators and freezers. The committee is composed of data from vaccine manufacturers , pediatricians, state health authorities, refrigeration manufacturers and industry experts from other interested parties who have spent the past six years working to develop the new standard. The committee needs to address several challenges. These challenges include overcoming the automatic thaw cycles present in many freezers that can take the vaccine out of its recommended storage conditions, and the inability of refrigerators to maintain strict temperature tolerances, or the potential for freezing due to differences in load or environmental conditions condition. The committee issued vaccine storage guidelines in June 2021. The new standard will help ensure that refrigerators and freezers certified to the standard and used for vaccine storage are designed and manufactured to help maintain the efficacy of the vaccines stored in them. When choosing vaccine storage equipment, carefully consider your freezer and refrigerated storage requirements, available space in your facility, and most importantly, equipment design. Choose a unit with a cold wall freezer section specially designed from the ground up to eliminate temperature spikes caused by freezer defrost cycles and refrigerators that maintain uniform temperature uniformity regardless of product load while protecting product from freezing is crucial. When shopping for a dedicated refrigerator, there are a few key issues to consider. Does the refrigerator maintain that temperature range throughout the cabinet? This consideration is key so vaccines can be stored uniformly on any approved shelf within the unit. How reliable is the refrigerator? You should look for vaccine refrigerators with long-term, consistent performance records. Do refrigerators meet current and emerging CDC, NSF, and ANSI guidelines that include stringent storage requirements for vaccines and biologicals? Following the recommended guidelines is the most effective way to ensure that no vaccines are wasted and no pets are left unprotected. Consistency, recovery and reliability are the most important factors in any vaccine storage. Check out vaccine storage refrigerator manufacturer thchamber for more information.
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  • Configuring Your Lab Oven
    Feb 15, 2022
    Laboratory ovens or laboratory drying ovens are high temperature ovens that are standard equipment in most clinical, forensic, electronic, materials processing and research laboratories. They provide uniform and precise temperature control for functions such as heating, baking, evaporation, sterilization and other industrial laboratory functions. Laboratory oven temperatures typically range from ambient to over 300°C. They are available in gravity (natural), mechanical (forced) convection and vacuum pumps for conventional heating and drying applications. For laboratories with temperature uniformity, stability and accuracy requirements, advanced protocol ovens are available to meet such demanding requirements. Laboratory ovens are widely used in industries such as biotechnology, pharmaceuticals and materials manufacturing. These industries often require the processes of baking, curing, annealing and drying materials with different chemical and physical compositions. The end results of many of these process applications are unique and therefore require various types of laboratory ovens. What to Consider Before Buying an Oven for Your Facility? There are certain things you must keep in mind before choosing the right oven for your process. Let's take a brief look at them. Determine the application: The first step in configuring an oven is to determine its application. There is a wide range of heating applications. Drying boxes are usually used for the following purposes: paint curing polymer curing Adhesive cure product drying Also, you have to consider the environment in which the oven will be used. If you're using it in a lab, you can opt for a small oven that has the ability to produce test results. China vacuum Drying oven The oven is designed to remove moisture from the oven to dry samples as quickly as possible. The dry box process quickly dries the sample by introducing fresh dry air into the chamber while exhausting warm moist air. Drying ovens provide high performance drying and heating. You'll notice that ovens are more expensive than standard lab ovens, mainly because ovens have drying capabilities that lab ovens lack. An oven requires an airflow system that can extract moisture from the air, which may or may not be necessary depending on your requirements. Laboratory oven Laboratory ovens, on the other hand, are designed to heat samples only. Unlike a drying oven, a lab oven will circulate the same air indoors. Therefore, laboratory ovens can only provide heating. A lab oven is a more cost-effective option than a drying oven and would be a suitable option if all you need is heating functionality. You may notice that lab ovens have a higher temperature range than drying ovens, so make sure the oven you choose can reach your desired temperature. In addition, you have to consider several other factors such as maximum operating temperature, type of material to be dried in the oven, maximum weight to be dried in an hour, etc. Reliable manufacturer. XCH Biomedical is one of the leading china drying oven manufacturers.
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  • Why you need a medical grade refrigerator
    Feb 08, 2022
    Medical grade refrigerator, also known as "lab" or "pharmacy" refrigerators, are significantly more expensive than standard household refrigerators.   In the blog, we'll look at this in more detail and explain why it's often not acceptable to use a household refrigerator to store samples or drugs in your lab.   What temperature do you want to reach? A basic but important question: what is the minimum temperature you need? This will depend on what you store in your lab freezer. Temperature range is important because prices vary widely depending on how low you want to go. For example, a standard -20°C freezer is much less expensive than a -86°C ultra-low temperature freezer. It is not uncommon for a difference of 2°C to 4°C between the top shelf of a domestic refrigerator and the bottom of the refrigerator compartment. Of course, this is perfectly acceptable when storing food or drinks. However, this is not acceptable when storing medicines or patient samples.   Safety Features of Laboratory Freezers You may also want to consider buying a refrigerator with a built-in high and low alarm in case the user leaves the door open or the appliance experiences a temperature failure. Some models also alert you if there's a power failure, which is useful if the refrigerator's power is a little choppy.   Alternatively, you may not need these alerts. Especially if you're opting for a separate temperature monitoring system. There are many different types of temperature monitoring systems out there. The XCH Biomedical medical refrigerator safety system provides multiple protections: compressor overheating, overpressure, overload protection and fan overheating protection. Multiple alarms: perfect sound and light alarm system, items are safer.   Stronger door construction The doors of medical refrigerators can be opened and closed dozens of times a day. This is why door seals and hinges are stronger because they are designed for heavy use.   Optional accessories for laboratory freezers There are a variety of optional accessories for your laboratory freezer. You need to decide what is really needed and what you don't have.   For example, do you need to move your refrigerator regularly? If so, you should have the unit equipped with casters. Do you store volatile substances? Better invest in a sparkless lab freezer. Is there an existing remote temperature monitoring system that needs to be compatible with the freezer? It's best to get a unit with built-in access ports so any probe can fit inside.   Before purchasing, please confirm with medical refrigerator manufacturers thchamber what features the end user really needs.
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  • How to Choose a Lab Oven
    Jan 17, 2022
    Several industries rely on industrial ovens for various processes such as baking, curing, heating, annealing, heat treating, sterilizing and aging. Additionally, these ovens are typically large and capable of handling larger volumes. Thus, effectively simplifying the manufacturing or manufacturing process in your industry.   If you've ever been in the market for an oven for your lab, you've probably come across standard lab ovens and drying ovens. It may be a common misconception that these two types of ovens are the same, but they are actually two different devices.   Laboratory oven Laboratory ovens are designed to heat samples only. Unlike a drying oven, a lab oven will circulate the same air indoors. Therefore, laboratory ovens can only provide heating. Lab ovens are more cost-effective than drying ovens and would be a suitable choice if all you need is heating functionality. You may notice that lab ovens have a higher temperature range than drying ovens, so make sure the oven you choose can reach your desired temperature.   Drying oven The oven is designed to remove moisture from the oven chamber to dry samples as quickly as possible. The dry box process quickly dries the sample by introducing fresh dry air into the chamber while exhausting warm moist air. Drying ovens provide high performance drying and heating. You'll notice that ovens are more expensive than standard lab ovens, mainly because ovens have drying capabilities that lab ovens lack. An oven requires an airflow system that can extract moisture from the air, which may or may not be necessary depending on your requirements.   Application Heat in an oxygen-free atmosphere to prevent sample corrosion or scaling. Drying, low temperature drying, aging testing, moisture determination and chemical resistance studies. Ideal for pharmaceutical/food drying and electronics   For the best vacuum ovens, you can rely on XCH Biomedical. We also have many years of experience in manufacturing laboratory ovens and vacuum ovens. Contact us today to learn about our wide range of products.
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  • Purchase a new laboratory medical refrigerator
    Jan 05, 2022
    Pharmacies, hospitals, and laboratories rely on cold storage devices to protect drugs and vaccines. These devices create the best conditions for prolonging the shelf life of these beneficial drugs. Medical institutions are facing increasing pressure to ensure consistent and reliable refrigeration to store temperature-sensitive drugs, vaccines, reagents, and patient samples. Unfortunately, some clinics try to save money by buying home freezers or refrigerators. When refrigerators used in clinical applications cannot provide a safe storage environment, it will have a major impact.   Medical-grade refrigerators (also called special refrigerators) are specially designed to store vaccines and are the preferred type. These units have microprocessor-based control for a more precise temperature range, and fans that provide forced air circulation to limit cold/hot spots and promote a more uniform temperature throughout the storage box.   Laboratory Refrigerator The most basic type of medical refrigerator is called laboratory refrigerator for short. They use precise digital displays to display the temperature. They are easy to clean, equipped with alarms and locks, and are ideal for storing or cooling medical tools and samples.   How to choose a medical refrigerator Temperature requirement First, understand the ideal temperature range for the items you are going to store. Different samples, vaccines and equipment require different temperatures. The smaller the possible temperature difference, the more stable the refrigerator temperature control.   Storage design Another important consideration for Temperature Controlled Medicine Storage Refrigerator is storage design. For example, if you are storing small samples, you need a different design than storing large containers. Organization is the key, as well as the uniform temperature throughout the storage process.   Temperature monitor One of the most important things a medical refrigerator does is to accurately track the internal temperature. Temperature readings need to be accurate at all times. The thermometer should display the internal temperature, not just the temperature set by the staff. Make sure that the thermometer is properly calibrated. You also need a data logger compatible with the refrigerator to record temperature readings. In this way, you don't have to rely on staff to record the temperature.   XCH Biomedical is a trusted manufacturer of high-quality medical equipment. We produce excellent medical refrigerators and freezers for laboratories, hospitals and doctor's offices. Our medical-grade equipment complies with CDC and FDA recommendations. For more information on medical refrigerators and freezers used for vaccines, check out our most popular selection of medical-grade refrigerator.
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  • Choosing the right walk-in stability test chamber
    Dec 21, 2021
    Companies buy walk-in stability test chamber for different reasons. The most obvious need is size. Large or odd-shaped products are not necessarily suitable for the scope of the floor model test chamber, especially when you consider the airflow ratio (the volume of the product and the volume of the work space are one to three). Other companies choose walk-in test chambers to accommodate a large number of products (thousands of mobile phones, for example), or to allow engineers to observe products up close during testing. The former case can improve the test efficiency, the latter case is only possible in a huge internal working space. The walk-in stability test chamber can be customized according to the volume and shape, performance, air quality (if people stay in the chamber), etc. You can even add an anteroom to separate the test chamber space from the laboratory. So, although you can find similar performance in floor-standing models (or desktops for that matter), you can only achieve this level of customization through a walk-in test chamber. Advantage The size is almost unlimited, so a lot of shelf space/samples can be accommodated A qualification covers a lot of shelf space Due to the larger size, the conditions of walk-in test chamber tend to be more stable Shortcoming A defective chamber can cause problems with a large number of samples Installation usually requires construction, electronics and refrigeration skills The compressor will increase the floor space or the distance, so it will increase the cost Identification requires additional probes Spare parts may be unique to the special construction They usually require three-phase power and additional water supply For safety reasons, the time the operator spends indoors may be limited Island space is necessary footprint waste There are many factors to consider when researching a walk-in test test chamber. With such a large capital purchase, you cannot ignore any details. Consult your entire team. Work hard to understand your testing requirements. Most importantly, contact an experienced test chamber manufacturer who can build a customized solution within your budget. Learn more about XCH Biomedical custom walk-in constant stability chamebr series.
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  • Photo Stability Test Chamber
    Dec 15, 2021
    Sunlight is a powerful force. The sun emits radiation in most of the electromagnetic spectrum, including a large amount of ultraviolet radiation. Although part of the solar radiation is absorbed by the earth’s atmosphere, there is still a considerable amount of radiation reaching the earth’s surface (as shown in the picture on the right). Ultraviolet rays can break the molecular bonds in the objects they strike. Most people are familiar with this effect on old paper products and other items. When they are exposed to sunlight, the chemical bonds are broken down, causing the color to fade. This discoloration effect is called photo degradation. However, the color of the object is not the only thing affected. The chemical properties of objects are affected, so these effects are extremely important to the pharmaceutical, cosmeceutical, and nutraceutical industries. There is a need to avoid chemical breakdown in drugs or vitamins, so it is important to ensure that drugs and nutrients remain stable during the expected shelf life of exposure to light. This is done by testing the light stability of the product. Light stability affects product shelf life, handling and packaging. This test is an important part of the drug development process. Light stability studies are usually conducted in a continuous manner, first testing drugs/supplements. Then, the product is tested first in its direct packaging, followed by the final marketing packaging that will be placed on the retailer's shelf. These tests can be repeated repeatedly until they prove that the drug can be sufficiently protected from light. Pharmaceutical manufacturers must establish the stability of their drugs to light. But what makes drug molecules or preparations unstable to light, and how to give them proper protection? Why do drug molecules degrade under light? First, drug molecules can directly absorb light. For this reason, the spectrum of the light source must overlap with the absorption spectrum of the molecule to some extent. Therefore, molecules that can absorb light of 320 nm or higher are at risk of photostability. The second way light causes photodegradation is through a process called photosensitization. This is where another component of the formulation absorbs light energy and then transfers it to the drug molecule, leading to degradation. To illustrate this effect, Figure 4 shows the structure and UV absorption spectrum of Losartan. We do not want losartan to have a photodegradation risk, and it has been proven to be photostable in most formulations. However, in liquid oral preparations containing cherry flavoring, losartan is sensitive to light [2]. Of course, cherry flavoring is colored and can absorb light. In addition, in the presence of oxygen, degradation occurs faster. The photodegradation reaction usually proceeds through the oxidation pathway. All companies that develop or manufacture drugs require a robust light stability testing process to ensure product quality and regulatory compliance. Inadequate testing can lead to costly delays and lost revenue. The 1996 guideline CPMP/ICH/279/95 Q1B describes the process of light stability testing of new active substances and pharmaceutical products. The output of cool white fluorescent lamps is similar to the output specified in ISO 10977 (1993). The spectral distribution of UVA fluorescent lamps is 320 nm to 400 nm, and the maximum energy emission is between 350 nm and 370 nm. Most waves must be in the range of 320 nm to 360 nm and 360 nm to 400 nm. The sample should be exposed to at least 1.2 million lux-hours under visible light (VIS) and at least 200 watt-hours per square meter under UVA. For more information, please refer to thchamber Photo Stability Test Chamber product page.
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  • Laboratory biochemical incubator and mildew incubator
    Dec 08, 2021
    The purpose of the laboratory incubator is to provide a controlled and pollution-free environment for the safe and reliable work of cell and tissue cultures by adjusting conditions such as temperature, humidity and CO2. Laboratory incubators are essential for the growth and storage of bacterial culture, cell and tissue culture, biochemical and hematological research, pharmaceutical work, and food analysis. According to the different temperature control range, the laboratory incubator is suitable for different fields. XCH Biomedical has biochemical incubators, which are widely used in scientific research and production departments such as environmental protection, sanitation and epidemic prevention, agricultural, livestock and aquatic products, drug testing, cell culture, etc.; bacterial incubators, mainly mold incubators. The mold incubator is a special constant temperature equipment for BOD detection of water body analysis, mold and other microorganism cultivation, and is widely used in research institutions for sanitation and epidemic prevention, agriculture, animal husbandry and aquatic products. In addition, we also have industrial incubators, heating incubators for scientific research and industrial production such as medical and health, pharmaceutical industry, biochemistry and agricultural sciences for bacterial cultivation, fermentation and constant temperature testing. The laboratory incubator is a heated insulated box used to cultivate and maintain microorganisms or cell cultures. The incubator maintains the optimal temperature, humidity and gas content of the internal atmosphere. Many incubators include a programmable timer that can be set to cycle between different temperature and humidity levels. Incubators vary in size, from desktop units to large cabinet-sized systems. There are many different types of laboratory incubators, including dry bath incubators with single or double blocks, mold incubators and biochemical incubators, biological oxygen demand (BOD) devices suitable for insect or plant research, shaking incubators, Hybridization furnace, bioreactor and various laboratory test rooms. What is the difference between a mold incubator and a biochemical incubator? 1. The difference in use The laboratory mildew incubator is used by universities, medical, military, electronics, chemistry, and biological research departments for bacteria storage and biological cultivation. It is a necessary testing equipment for scientific research laboratories. Biochemical incubators are widely used in environmental protection, sanitation and epidemic prevention, drug inspection, agriculture, animal husbandry, aquaculture and other scientific research, institutions, production departments, water quality analysis and BOD determination, bacteria, mold, microbial cultivation, preservation, plant cultivation, breeding experiments, special constant temperature equipment. Because it is not used, the mold incubator is equipped with a germicidal lamp, but the biochemical incubator is not installed. 2. The difference in function The functional difference between mold incubator and biochemical incubator is the difference between humidity control and killing functions. The biochemical incubator does not have the function of regulating and not killing, but also has the function of regulating and killing. The mold incubator has two options of humidification and non-humidification. The biochemical incubator does not have the humidification option. In many cases, there is no humidification and mold incubator. The biochemical incubator has the difference in UV disinfection function.
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